Search results for "P1 purinoceptor"
showing 3 items of 3 documents
A1 receptor-mediated modulatory effects of adenosine on the contractility in mouse ileum: characterization of signal transduction pathway
2008
"A1 receptors mediate the inhibitory effects of adenosine on the contractility in mouse ileum.”
2008
A1 receptors mediate adenosine inhibitory effects in mouse ileum via activation of potassium channels.
2008
Abstract Aims We investigated the effects induced by exogenous adenosine on the spontaneous contractile activity of the longitudinal muscle of a mouse ileum, the receptor subtypes activated, the involvement of enteric nerves and whether opening of K + channels was a downstream event leading to the observed effects. Main methods Mechanical responses of the mouse ileal longitudinal muscle to adenosine were examined in vitro as changes in isometric tension. Key findings Adenosine caused a concentration-dependent reduction of the spontaneous contraction amplitude of the ileal longitudinal muscle up to its complete disappearance. This effect induced was markedly reduced by an A 1 receptor antago…